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Citation: Shi Jingmin, Liao Daizheng, Cheng Peng, Miao Mingming, Jiang Zonghui, Liu Yongjiang, Wang Genglin. Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes[J]. Chinese Journal of Applied Chemistry, ;1996, 13(4): 86-88. shu

Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes

1.
Department of Chemistry, Nankai University, Tianjin 300071

Received Date: 30 October 1995
Available Online: 9 April 1996
Fund Project:

Two new novel binuclear cobalt (Ⅱ) complexes, namely,[Co₂(4PT)(Phen)₄](ClO₄)₂·3H₂O (complex 1) and[Co₂(4PT)(NPhen)₄] (ClO₄)₂·2H₂O (complex 2) (4PT=4-nitrophthalato, Phen=l,10-phenanthroline, NPhen=5-nitro-1,10-phenanthroline) have been synthesized. The complexes were characterized by elemental analysis, IR, UV-Vis spectra and electronic conductance. The variable-temperature magnetic susceptibility of the complexes was measured over 77~300 K. The data were analyzed by using the magnetic susceptibility equation based on Heisenberg spin-exchange operator, and the exchange integrals for complex 1 and complex 2 were found 2J=-8.6 cm^-1 and 2J=-4.3 cm^-1,respectively. Experiments of inhibiting human leukemia cell, stomach cancer cell and carcinoma of nasopharyngeal cancer cell in vitro were made,and found that the complexes exhibited a relatively strong function of inhibiting these three kinds of cancer cells.
- nitrophthalate,
- binuclear Co(Ⅱ) complex,
- magnetism,
- bioactivity
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