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Citation: Liu Xiang, Li Jiguo, Zhang Zheng. Catalytic Asymmetric Reduction of Prochiral Ketones in the Presence of Chiral Quinine-Co(Ⅱ) Complex[J]. Chinese Journal of Applied Chemistry, ;1997, 14(4): 88-90. shu

Catalytic Asymmetric Reduction of Prochiral Ketones in the Presence of Chiral Quinine-Co(Ⅱ) Complex

1.
1. Department of Chemical Engineering, Wuxi University of Light Industry, Wuxi 214036;
2.
2. Department of Chemistry, Nanjing University, Nanjing

Received Date: 25 October 1996
Available Online: 22 April 1997

A chiral complex, in situ prepared from (-)-quinine and CoCl₂ was used as catalyst for asymmetric reduction of aromatic prochiral ketones:p-R₂C₆H₄COR₁(R₁, R₂ shown in Tab.1) and some products with moderate enantiomeric excesses were obtained. Effects of KBH₄ and LiAlH₄ as reductant and reaction temperature and time on the reaction were investigated.
- chiral complex,
- asymmetric reduction,
- aromatic prochiral ketone
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