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Citation: Shi Zhenmin, Liu Shengkun, Zhang Zhulian, Gong Yujun. Inhibition of Basic Hydrolysis Reaction of Aspirin by Micelles of Ionic Surfactants[J]. Chinese Journal of Applied Chemistry, ;1997, 14(1): 110-112. shu

Inhibition of Basic Hydrolysis Reaction of Aspirin by Micelles of Ionic Surfactants

1.
Department of Chemistry, Yanan University, Yanan 716000

Received Date: 4 May 1996
Available Online: 12 August 1996

Cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) were used as surfactants and effects of micelles on the basic hydrolysis of aspirin (ASP) were studied spectrophotometrically. When the concentrations of CTAB are larger than 7.3×10^-3 mol/L, there is an inhibition of basic hydrolysis of ASP, the best concentration being 3.25×10^-3 mol/L. At a constant concentration of CTAB, the addition of a small amount of SDS causes the inhibition of CTAB to decrease, indicating that SDS takes part together with CTAB in the formation of mixed micelles.
- surfactant,
- aspirin,
- basic hydrolysis,
- micelle,
- inhibition
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