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Citation: LI Shuo, ZHOU Cheng-He, CHEN Jia-Xuan, XIANG Qing-Xiang. Ethidium Bromide Fluorescence Probe on the Interaction between Dinuclear Macrocyclic Polyamine Zn(Ⅱ) Complex and DNA[J]. Chinese Journal of Applied Chemistry, ;2009, 26(6): 1461-1465. shu

Ethidium Bromide Fluorescence Probe on the Interaction between Dinuclear Macrocyclic Polyamine Zn(Ⅱ) Complex and DNA

1.
a Department of Chemistry and Chemical Engneering, Southwest Univercity, Chongqing;
2.
b Department of Chemistry and Life Science, Leshan Teachers College, Leshan 614004

Corresponding author: XIANG Qing-Xiang,
Received Date: 16 December 2008
Available Online: 7 May 2009
Fund Project: 四川省科技厅应用基础项目(04JY029-018) (04JY029-018)四川高校重点实验室专项(2006ZD049) (2006ZD049)乐山市重点科技计划(06GZD043)资助项目 (06GZD043)

A novel dinuclear macrocyclic polyamine Zn(Ⅱ) complex was synthesized from 1,4,7,10-tetraazacyclododecane,the structures of the compounds were characterized by ¹H NMR,MS and elemental analysis.The interactions between calf thymus(CT) DNA and these compounds were investigated by fluorometric detection.The fluorescence intensity of the DNA/EB system was decreased to 47.3% of that of the initial system at c_{complex 6}/c_DNA=0.51,which indicates that the dinuclear complex was inserted into the CT DNA.The order of fluorescence quenching values of the DNA/ethidium bromide(EB) systems by these compounds is as follows:dinuclear macrocyclic polyamine Zn(Ⅱ) complex> dinuclear macrocyclic polyamine ligand> Cyclen-Zn(Ⅱ) complex> Cyclen.
- dinuclear macrocyclic polyamine,
- Zn(Ⅱ) complex,
- synthesis,
- CT DNA,
- fluorescence
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