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Citation: ZHANG Ming, LU Jun-Rui, XIN Chun-Wei, LIU Fang, ZHOU Chang-Ming, BAO Xiu-Rong, CHEN Li-Ran. Synthesis,Characterization and Antibacterial Activities of 5-Bromo-2-hydroxybenzoyl Substituted Aromatic Aldehyde Hydrazones[J]. Chinese Journal of Applied Chemistry, ;2009, 26(6): 1386-1390. shu

Synthesis,Characterization and Antibacterial Activities of 5-Bromo-2-hydroxybenzoyl Substituted Aromatic Aldehyde Hydrazones

1.
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384

Corresponding author: LU Jun-Rui,
Received Date: 1 November 2008
Available Online: 20 March 2009
Fund Project: 国家自然科学基金(20576103,20776114) (20576103,20776114)天津市自然科学基金(05YFJIYJC14000) (05YFJIYJC14000)天津市高校科技发展基金(2006ZD33,20050712)资助项目 (2006ZD33,20050712)

Seven 5-bromo-2-hydroxy benzoyl substituted aromatic aldehyde hydrazones were synthesized with methyl salicylate as raw materials via bromination,hydrazination and condensation reactions,respectively.Three novel compounds were reported.The structures of all the synthesized compounds were confirmed by ¹H NMR,IR,mass spectra and elemental analysis.The result of preliminary bioassay shows that the title compounds have obvious selective antibacterial activities to different classificatory bacterium at 0.05%(mass concentration),and have 100% inhibitory rate on Monilia albican and Bacillus subtilis.They will be a kind of potential antibacterial compounds against fungus and Gram-positive bacteria.5-Bromo-2-hydroxyphenyl-3',5'-dibromo-o-hydroxyphenyl substituted aromatic aldehyde hydrazone has the same antibacterial activity as triclosan.The analysis of structure activity shows that the antibacterial activities are related to the kind of Ar-ring and its substituent groups.The antibacterial activities are reduced by electron-donating groups,such as o-,p-OH,—OCH₃ of Ar-ring,however,they are enhanced by the m-substituted halogen groups of Ar-ring.
- bromo-hydroxy benzoyl substituted aromatic aldehyde hydrazone,
- methyl salicylate,
- synthesis,
- characterization,
- antibacterial activity
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