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Citation: CHEN Shao-Rui, MA Ji-Hai, ZHOU Xue-Qin, LIU Dong-Zhi. A Novel Synthetic Method of 1,2-Cyclododecandione[J]. Chinese Journal of Applied Chemistry, ;2009, 26(11): 1374-1376. shu

A Novel Synthetic Method of 1,2-Cyclododecandione

1.
a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;
2.
b College of Science, Hebei University of Science and Technology, Shijiazhuang

Corresponding author: LIU Dong-Zhi,
Received Date: 28 October 2008
Available Online: 25 February 2009
Fund Project: 河北省自然科学基金(B200400278)资助项目 (B200400278)

1,2-Cyclododecandione(4) was synthesized from dodecanedioic acid via esterification,acyloin condensation,oxidation in an overall yield of 43.1%.Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester(2) with a yield of 86.5%.Compound 3 was obtained from compound 2 through acyloin condensation and the yield reached up to 63.1%,which was oxidized to compound 4 by bromine water as the oxidation reagent with a yield of 79%.The target compound was a light yellow crystal and was characterized by means of IR,¹H NMR and ¹³C NMR.
- dodecanedioic acid,
- acyloin condensation,
- cyclododecandione
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