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Citation: LIU Nian-Jin, CAO Song, MA Yan-Ming, SHEN Li, QIAN Xu-Hong. Solvent-free Ugi Four-component Synthesis and Insecticidal Activities of Novel Fluorine-Containing Philanthotoxins-12 Derivatives[J]. Chinese Journal of Applied Chemistry, ;2009, 26(10): 1159-1164. shu

Solvent-free Ugi Four-component Synthesis and Insecticidal Activities of Novel Fluorine-Containing Philanthotoxins-12 Derivatives

1.
Shanghai Key Laboratory of Chemical Biology, Center of Fluorine Chemical Technology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237

Corresponding author: QIAN Xu-Hong,
Received Date: 11 September 2008
Available Online: 19 December 2008
Fund Project: 国家重点基础研究发展规划“九七三”项目(2003CB114405) (2003CB114405)

Eight novel fluorine-containing PhTX-12 derivatives were prepared from the intermediate obtained via one-pot Ugi four-component solvent-free reactions by the simple removal of the protecting groups in the presence of trifluoroacetic acid. Their structures were identified by ¹H NMR,¹³C NMR and HRMS or MS. Preliminary bioassays indicate that compound 6b showed 44% and 42% mortality rates against Heliothis armigera and Pieris rapae respectively at a concentration of 100 mg/L.
- Philanthotoxin,
- solvent-free synthesis,
- Ugi 4-CR,
- insecticidal activity
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