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Citation: QIAN Hua, LIU Da-Bin, WANG Liang. New Synthetic Method for 4-Methoxy-7H-Furo[3,2-g] benzopyran-7-one[J]. Chinese Journal of Applied Chemistry, ;2009, 26(9): 1084-1087. shu

New Synthetic Method for 4-Methoxy-7H-Furo[3,2-g] benzopyran-7-one

1.
College of Chemistry, Nanjing University of Science and Technology, Nanjing 210094

Corresponding author: QIAN Hua,
Received Date: 29 August 2008
Available Online: 5 March 2009

A novel and simple method for the preparation of 4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one was proposed.The target compound was synthesized from phloroglucinol as the starting material by etherification,iodination,Pechmann condensation,coupling reaction,hydrolysis and decarboxylation.The intermediates and the target compound were characterized by IR,MS and ¹H NMR.The proper technological parameters were ascertained by experiments,and the feasibility of the route to linear furanocoumarins by regiosele-ctive iodination,Pechmann condensation and coupling reaction was studied.All the reactions were performed under normal pressure and mild conditions in the presence of an inexpensive catalyst followed by relatively simple post treatment.It is a new method with a total yield of 12% for the preparation of furanocoumarins.
- furanocoumarins,
- bergapten,
- phloroglucinol,
- total synthesis
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