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Citation: GUO Ying, BEI Yu-Xiang, GAO Yun-Tao. Electrochemistry and UV-Vis Spectrometry on Interaction between Breviscapine and DNA[J]. Chinese Journal of Applied Chemistry, ;2009, 26(9): 1045-1049. shu

Electrochemistry and UV-Vis Spectrometry on Interaction between Breviscapine and DNA

GUO Ying ^a,b ,
BEI Yu-Xiang ^a ,
GAO Yun-Tao ^a,,

1.
a College of Chemistry and Bio-Science, Yunnan Nationalities University, Kunming 650031;
2.
b Department of Chemistry, Yunyang Teachers College, Danjiangkou

Corresponding author: GAO Yun-Tao,
Received Date: 15 July 2008
Available Online: 20 November 2008
Fund Project: 云南省社会发展科技计划项目(2007B148M) (2007B148M)

The interaction between breviscapine and DNA was studied by electrochemical tests.The results show that the oxidation peak current of breviscapine decreased and the peak potential shifted positively in the presence of DNA.The absorption spectrum measurement shows that with the addition of DNA,the intensity of absorption peak of breviscapine at 335 nm decreased,showing hypochromic effect,at the same time,two isoelectric absorption point appeared.The results indicate that breviscapine interacts with DNA mainly through intercalation.Calculation indicats that the binding ratio between breviscapine and dsDNA was 1:3,with a binding constant of 3.63×10¹³.
- Breviscapine,
- DNA,
- cyclic voltammetry,
- UV-Vis spectrometry,
- interaction
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