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Citation: YANG Zhi-Kun, SUN Xue-Jun, MI Na, ZHANG Hai-Ke, YOU Jin-Mao, FAN Zhi-Jin. Synthesis and Fungicidal Activity of Triazolothiadiazole Derivatives[J]. Chinese Journal of Applied Chemistry, ;2009, 26(9): 1027-1030. shu

Synthesis and Fungicidal Activity of Triazolothiadiazole Derivatives

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a Department of Chemistry, Qufu Normal University, Qufu;
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b State Key Laboratory of Elemento Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: FAN Zhi-Jin,
Received Date: 20 September 2008
Available Online: 5 November 2008
Fund Project: 国家自然科学基金(20672062,20872071) (20672062,20872071)国家自然科学基金国际(地区)合作与交流项目/合作研究项目(20911120069) (地区)合作与交流项目/合作研究项目(20911120069)天津市自然科学基金(07JCYBJC01200) (07JCYBJC01200)国家重点基础研究发展计划“九七三”(2003CB114402) (2003CB114402)天津市科技支撑计划国际科技合作项目(07ZCGHHZ01400)资助项目 (07ZCGHHZ01400)

Eleven novel compounds were designed and synthesized from 3-substituted-4-amino-5-mercapto-1,2,4-triazoles with heterocyclic carboxylic acid via cyclization in the presence of phosphoryl chloride on the basis of the princple of combination of active structural moieties.All the compounds were characterized by melting point,IR,¹H NMR and elemental analysis.The results of bioassay experiments with 10 commonly used fungi show that all the compounds had satisfactory fungicidal activity against Botrytis cinerea,with the growth inhibition rate of compounds 5ae,5ag,5bd against Botrytis cinerea being up to 70% and that of 5ad,5cd,5ce against Botrytis cinerea more than 60%;compound 5bd exhibited fungicidal activity against Pellicularia sasakii with growth inhibition of up to 60%,and the growth inhibition rate of compound 5cg against Colletotrichum lagenarium was 69%.
- triazolothiadiazole,
- 3,6 point-substituted derivatives,
- synthesis,
- fungicide
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