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Citation: GAO Li-Di, SUN Peng, LI Qiu-Fang, HAO Xiu-Ju. Chiral Separation of Oxybutynin Enantiomers by High-Performance Capillary Zone Electrophoresis[J]. Chinese Journal of Applied Chemistry, ;2009, 26(8): 1002-1004. shu

Chiral Separation of Oxybutynin Enantiomers by High-Performance Capillary Zone Electrophoresis

1.
Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006

Corresponding author: GAO Li-Di,
Received Date: 26 July 2008
Available Online: 20 September 2008

Oxybutynin chloride enantiomers were separated with capillary zone electrophoresis(CZE) with hydroxypropyl-β-cyclodextrin(HP-β-CD) as the chiral selector,and the difference between enantioseparation abilities of HP-β-CD and β-CD was compared.The best experimental conditions for hydrochloric oxybutynin enantiomers in baseline separation were obtained,including water-soluble hydroxypropyl-β-cyclodextrin concentration,background buffer pH,capillary temperature,voltage and the amount of three hydroxymethyl-methane in phosphate background buffer,and so on.The method is simple,quick with an improved reprodu-cibility.
- capillary zone electrophoresis,
- oxybutynin,
- enantioseparation,
- hydroxypropyl-β-cyclodextrin
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