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Citation: WANG Chun-Ling, YANG Jin-Feng, CHEN Si-Yu, LI Bing-Qi. Design,Synthesis and Biological Activity of Pyrazole Hydrazones and Diheterocyclic Compounds[J]. Chinese Journal of Applied Chemistry, ;2009, 26(8): 961-965. shu

Design,Synthesis and Biological Activity of Pyrazole Hydrazones and Diheterocyclic Compounds

1.
a Department of Life Science, Shihezi University, Shihezi 832003;
2.
b College of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003

Corresponding author: LI Bing-Qi,
Received Date: 20 August 2008
Available Online: 5 December 2008
Fund Project: 石河子大学高层次人才启动资金专项资助项目(RCZX200632) (RCZX200632)

The active intermediate substitution-4-formacyl pyrazole was obtained from benzene hydrazone via the Vilsmeier-Haak reaction.Then it reacted with 4-substituted aryloxyacetyl hydrazine to form compounds 3.Finally Bis-heterocyclic compounds 4 were synthesized via cyclic reaction.All the newly synthesized compounds have not been reported and their structures have been established on the basis of IR,¹H NMR,MS spectral data and elemental analysis.Compounds 3 and 4 underwent a preliminary test of antibacterial activity against Fusarium oxyaporium,Verticillium dahliae,Rhizoctonia solani,Pychium aphanidermatum,Alternaria solani,Sclerotinia sclerotiorum.The results show that the inhibiting rates of the bis-heterocyclic compounds 4 are higher than those of the pyrazole hydrazones 3 obviously.Compounds 3d and 3e showed good inhibitory activities(>80%) against Alternaria solani and Sclerotinia sclerotiorum at a concentration of 50 mg/L.In contrast,bis-heterocyclic compounds 4 have obviously inhibitory activities(>70%) against these six germs and compounds 4d and 4e showed inhibitory activities(>95%) against Rhizoctonia solani.
- pyrazole,
- oxadiazole,
- synthesis,
- fungicidal activity
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