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Citation: FU De-Cai, ZHANG Jing, LI Zhi-Wei, HA Jing. Kinetics on Nucleophilic Substitution Reaction of Pyridine with 7-Phenylacetamido-3-chloridecephem-4-carboxylic Acid p-Methoxybenzyl Ester Iodide[J]. Chinese Journal of Applied Chemistry, ;2009, 26(8): 890-893. shu

Kinetics on Nucleophilic Substitution Reaction of Pyridine with 7-Phenylacetamido-3-chloridecephem-4-carboxylic Acid p-Methoxybenzyl Ester Iodide

FU De-Cai ^a,, ,
ZHANG Jing ^a,b ,
LI Zhi-Wei ^a ,
HA Jing ^a

1.
a College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018;
2.
b Department of Pharmaceutical Engineering, Hebei Chemical and Pharmaceutical Vocational Technology College, Shijiazhuang 050026

Corresponding author: FU De-Cai,
Received Date: 13 August 2008
Available Online: 20 November 2008
Fund Project: 河北省科学技术研究与发展计划项目(06547003D-2) (06547003D-2)

7-Phenylacetamido-3-pyridiniummethylcephem-4-carboxylic acid p-methoxybenzyl ester was prepared by the reaction of pyridine with 7-phenylacetamido-3-chloridecephem-4-carboxylic acid p-metho-xybenzyl ester iodide.The reaction process was inspected by HPLC in dichloromethane,acetone,tetrahydrofuran,the mixture of ethyl acetate and DMF.It was determined that the nucleophilic substitution reaction was a 2nd order reaction.In a given solvent the rate of the reaction perfectly obeyed Arrhenius's equation within the experimental temperature of 25 ℃ and 35 ℃.The activation energy and the preexponential factor were obtained,and the solvent effects were discussed.The activity order of the nucleophilicity in different solvents is as follows:acetone> tetrahydrofuran> the mixture of ethyl acetate and DMF> dichloromethane.
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