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Citation: WU Xiao-Yun, HU Ai-Xi. Synthesis of Calcium Antagonist Nitrendipine in Ionic Liquid[J]. Chinese Journal of Applied Chemistry, ;2009, 26(6): 746-748. shu

Synthesis of Calcium Antagonist Nitrendipine in Ionic Liquid

WU Xiao-Yun ^a,, ,
HU Ai-Xi ^b

1.
a School of Pharmaceutical Science, Southern Medical University, Guangzhou 510515;
2.
b College of Chemistry and Chemical Engineering, Hunan University, Changsha

Corresponding author: WU Xiao-Yun,
Received Date: 10 June 2008
Available Online: 15 October 2008
Fund Project: 广东省卫生厅医学科学技术研究基金资助项目(B2007112) (B2007112)

The second-generation 1,4-dihydropyridine calcium antagonist nitrendipine was synthesized through the cyclocondensation process of ethyl 2-(3-nitrobenzylidene) acetoacetate and methyl 3-aminocrotonate in an ionic liquid,n-butyl pyridinium tetrafluoroborate,at 100~110 ℃ for 3 h in a yield of 95%.The ionic liquid can be recycled at 90% recovery,and can be reused at least 5 times without loss in activity.
- dihydropyridine calcium antagonist,
- nitrendipine synthesis,
- ionic liquid
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