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Citation: PAN Yong, WANG De-Cai, JIANG Jian. Synthesis of (4R,5R)-4,5-Bis(aminomethyl)-1,3-dioxolane[J]. Chinese Journal of Applied Chemistry, ;2009, 26(2): 237-239. shu

Synthesis of (4R,5R)-4,5-Bis(aminomethyl)-1,3-dioxolane

1.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009

Corresponding author: WANG De-Cai,
Received Date: 17 December 2007
Available Online: 20 February 2008
Fund Project: 江苏省研究生科研创新基金(2007)资助项目 (2007)

We developed a simple and efficient three-step method,that is,aldol condensation,aminolysis with gaseous ammonia and reduction by LiAlH4,to synthesize(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane.The average yield were 52.1%,higher than 22.4% reported in the literature.Five new compounds were synthesized with the new method,and their structures were confirmed by MS-ESI,¹H NMR and elemental analysis.
- aldol condensation,
- aminolysis,
- amide reduction,
- synthesis
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