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Citation: GAO Zhong-Jun, LIU Guang-Jun, YIN Han-Dong. Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C₄H₉)₂Sn(0.5·O₂CCH₂C₁₂H₈N)(0.5·C₂H₅O)]₂O}₂·(C₁₂H₈NH)[J]. Chinese Journal of Applied Chemistry, ;2009, 26(2): 140-143. shu

Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C₄H₉)₂Sn(0.5·O₂CCH₂C₁₂H₈N)(0.5·C₂H₅O)]₂O}₂·(C₁₂H₈NH)

1.
a Department of Chemistry, Ji'ning College, Qufu 273155;
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b Department of Chemistry, Liaocheng University, Liaocheng

Corresponding author: GAO Zhong-Jun,
Received Date: 13 January 2008
Available Online: 18 May 2008
Fund Project: 国家自然科学基金(20271025) (20271025)山东省教育厅科研基金(J07WC03)资助课题 (J07WC03)

Organotin(Ⅳ) complex {[(n-C₄H₉)₂Sn(0.5·O₂CCH₂C₁₂H₈N)(0.5·C₂H₅O)]₂O}₂·(C₁₂H₈NH) was synthesized by the reaction of n-dibutyltin oxide with(9-carbazoly)-acetic acid.The complex was characterized by elemental analysis,IR and ¹H NMR.The crystal structure was determined by X-ray single crystal diffraction.The crystal belongs to monoclinic,with space group C_2/c with a=2.797 5(13) nm,b=2.153 4(10) nm,c=1.515 4(7) nm,β=118.759(6)°,V=8.003(7) nm₃,Z=4,μ=1.285 mm^-1,D_c=1.386 g/cm₃,F(000)=3 408,R=0.057 1,wR=0.136 2,GOF=1.005.The complex is a centrosymmetric structure mode with a four-member central endo-cyclic Sn₂O₂ unit in which two bridged oxygen atoms both connect with an exo-cyclic tin atom.The endo-cyclic tin atoms and the exo-cyclic tin atoms are all five-coordination and have a coordination geometry of a distorted trigonal bipyramid.This complex was tested in vitro against human tumour cell lines,MCF-7 and WiDr,and displayed high activity.
- organotin(Ⅳ) complex,
- (carbazoly)-acetic acid,
- synthesis,
- crystal structure,
- antitumor activity
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Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C4H9)2Sn(0.5·O2CCH2C12H8N)(0.5·C2H5O)]2O}2·(C12H8NH)

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Synthesis,Crystal Structure and Antitumor Activity of Organotin(Ⅳ) Complex{[(n-C₄H₉)₂Sn(0.5·O₂CCH₂C₁₂H₈N)(0.5·C₂H₅O)]₂O}₂·(C₁₂H₈NH)