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Citation: LI Wei-Si, SHI Qian, LI Zhen-Jiang. Two-step Efficient Synthesis of 2-Substituted Benzimidazoles without Catalyst[J]. Chinese Journal of Applied Chemistry, ;2009, 26(2): 130-134. shu

Two-step Efficient Synthesis of 2-Substituted Benzimidazoles without Catalyst

1.
College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009

Corresponding author: LI Zhen-Jiang,
Received Date: 6 January 2008
Available Online: 18 April 2008
Fund Project: 国家重点基础研究发展计划(2003CB716004)资助项目 (2003CB716004)

Several aromatic aldehydes and sodium bisulfite were mixed to prepare hydroxyl sulfonates,which were added to o-phenylenediamine or substituted o-phenylenediamine in refluxing ethanol to afford 2-substi-tuted benzimidazoles through oxidation by air directly.One of the fifteen synthesized compounds,2-(4-chlorophyenyl)-6-methoxyl-1H-benzimidazole has not been reported.All the compounds were identified by IR,¹H NMR spectra and elemental analysis.The method is simple,mild,eco-friendly and requires no catalyst.
- aromatic aldehyde,
- o-phenylenediamine,
- substituted benzimidazole,
- synthesis
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