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Citation: MA Gui-Juan, GONG Bo-Lin, YAN Chao. Preparation of L-Isoleucine-Type Polymer-bonded Chiral Ligand Exchange Stationary Phase and Enantiomeric Separation of DL-Amino Acids[J]. Chinese Journal of Applied Chemistry, ;2009, 26(2): 125-129. shu

Preparation of L-Isoleucine-Type Polymer-bonded Chiral Ligand Exchange Stationary Phase and Enantiomeric Separation of DL-Amino Acids

MA Gui-Juan ^a ,
GONG Bo-Lin ^a,b,, ,
YAN Chao ^b

1.
a Key Laboratory of Energy & Chemical Engineering, Ningxia University, Yinchuan 750021;
2.
b Unimicro(Shanghai) Technologies Co., Ltd., Shanghai 201203

Corresponding author: GONG Bo-Lin,
Received Date: 19 January 2008
Available Online: 9 April 2008
Fund Project: 科技部国际合作重点项目(2006DFA33690) (2006DFA33690)教育部新世纪优秀人才支持计划(NCET-04-0986) (NCET-04-0986)上海市博士后科研基金(06R214202)资助项目 (06R214202)

A new stationary phase was synthesized for chiral-ligand-exchange chromatography from a reaction of L-isoleucine with monodispersed poly(glycidylmethacrylate-co-ethylenedimethacrylate) particles.The enantiomeric resolutions of 12 DL-amino acids were achieved on the synthesized chiral ligand exchange chromatographic stationary phase with 0.2 mol/L NaAc and 0.1 mmol/L Cu(Ac)₂ aqueous solution as mobile phase and detection wavelength set at 254 nm.The enantioselectivities of the DL-amino acids separated were found to be in a range of 1.23~2.33.The effects of the chromatographic conditions,such as pH and temperature of column and flow rate of eluent,on the enantiomeric resolution of the DL-amino acids were studied.The thermodynamics in chromatographic separation were discussed.
- chiral ligand exchange chromatography,
- monodisperse resin,
- L-isoleucine,
- DL-amino acid,
- enantiomeric separation
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