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Citation: TAO Jian-Qi, FANG Zhi-Jie. Synthesis of Sucralose-based Amino Acid[J]. Chinese Journal of Applied Chemistry, ;2009, 26(1): 119-121. shu

Synthesis of Sucralose-based Amino Acid

TAO Jian-Qi ,
FANG Zhi-Jie ^,

1.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: FANG Zhi-Jie,
Received Date: 7 December 2007
Available Online: 6 May 2008

Sucralose was esterized regioselectively by protected amino acid using N,N'-dicyclohexylcarbo-diimide(DCC) as coupling reagent.The reaction led to the formation of an intermediate which has the ester group on C6 of the sucralose molecule.The final product was obtained by removing Fmoc in the solvent of morpholine/DMF(V/V,1:1).Fmoc protected phenylalanine and leucine were used in this paper to prepare 4 new compounds via regioselective esterification and deprotection reactions.The structures of products were characterized by ¹H NMR and ¹³C NMR.
- sucralose,
- amino acid,
- phenylalanine,
- leucine,
- regioselective
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