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Citation: WANG Ji-Fen, SUN Hong-Feng, YE Neng-Sheng, GU Xue-Xin, LI Wen-Jun, LI Ying. Determination of MDA and MDMA in Human Blood by Microwave Extraction-Gas Chromatography[J]. Chinese Journal of Applied Chemistry, ;2009, 26(1): 116-118. shu

Determination of MDA and MDMA in Human Blood by Microwave Extraction-Gas Chromatography

1.
a Department of Criminal Science and Technology, Chinese People's Public Security University, Beijing 100038;
2.
b Department of Chemistry, Capital Normal University, Beijing 100037

Corresponding author: GU Xue-Xin,
Received Date: 1 December 2007
Available Online: 11 April 2008
Fund Project: 中国人民公安大学院士基金资助项目(LG027-6) (LG027-6)北京市教育委员会共建项目建设计划资助(JD100410669) (JD100410669)

3,4-Methylenedioxyamphetamine(MDA) and 3,4-methylenedioxymethamphetamine(MDMA) in human blood were determined by means of microwave extraction-gas chromatography(GC).The optimal conditions included the pH of blood sample 13,ethyl acetate as extraction solvent,extraction at 30 ℃ for 10 min.The average recovery of MDA or MDMA with this extraction method was 96.7% or 101.7%,and the relative standard deviation of MDA or MDMA was 4.8% or 5.3%(n=5).The limit of detection was 5×10^-8 g/mL for MDA and MDMA in the blood.Using this method,MDA and MDMA need not to be derivatized and can be separated from the matrix.The results indicate that the method is rapid,accurate and sensitive,and can be used for the determination of MDA and MDMA in blood samples.
- microwave extraction,
- gas chromatography(GC),
- MDA,
- MDMA,
- blood
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