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Citation: Sun Qiang, Xu Jiping, Cai Shuxia, Zhang Jinlan, Zhang Xingchen, Ma Xueyan, Liu Dexuan, Cheng Yuhua, Jin Fengxie. SYNTHESIS OF DEXTRAN-SUPPORTED MACROCYCLIC MERCAPTAL CHELATING AGENT AND ITS ANTIDOTAL ABILITY FOR MERCURY P0ISONING[J]. Chinese Journal of Applied Chemistry, ;1983, 1(1): 28-32. shu

SYNTHESIS OF DEXTRAN-SUPPORTED MACROCYCLIC MERCAPTAL CHELATING AGENT AND ITS ANTIDOTAL ABILITY FOR MERCURY P0ISONING

1.
1. Changchun Institute of Applied Chemistry, Academia Sinica;
2.
2. Changchun Institute of Biological Products;
3.
3. Department of Chemistry, Jilin University, Changchun

Received Date: 18 March 1983

A new water-soluble polymeric selective chelating agent for mercury(Ⅱ) was prepared by the acid mercaptalation of the aldehyde derivative of dextran with ethylene glycol dithioglycolate. The product is composed of macrocyclic mercaptal groups linked to dextran. A preliminary examination of its acute toxicity and its ability to offset-acute mercuric chloride poisoning has been made. The results indicate that this chelating agent is relatively non-toxic and improves the survival rate of animals.It seems promising as an oral agent for the treatment of mercury poisoning and should be able to remove mercury from the enterohepatic circulation and increase its rate of excretion via the feces and urine.
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