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Citation: Ding Daoyuan, Hu Jiehan, Yang Zhiyong. REACTION KINETICS OF CDDP,CBDCA WITH GUANOSINE AND L-Met[J]. Chinese Journal of Applied Chemistry, ;1992, 9(3): 114-117. shu

REACTION KINETICS OF CDDP,CBDCA WITH GUANOSINE AND L-Met

1.
Dalian Institute of Chemical Physics, Academia Sinica, Dalian 116012

Corresponding author: Ding Daoyuan,
Received Date: 5 March 1991
Available Online: 27 January 1992

The reaction kinetics of CDDP (cisplatin), CEDCA (carboplatin) with guanosine and L-Met are compared by means of HPLC.The results show that the reaction rate of CDDP with Guo is greater than that with CBDCA. However, CBDCA gave more 1:2 products with Guo than 1:1 products and its second hydrolysis rate constant k₂ is much greater than its first one k₁.For reactions of CDDP and CBDCA with L-Met the second rate constants are measured as 36.1×10^-3 and 5.0×10^-3M^-1S^-1, respectively. This may be one of the reasons that CBDCA shows less nephrotoxicity than CBDP.
- cisplatin(CDDP),
- carboplatin(CBDCA),
- guanosine,
- L-Met,
- HPLC
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