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Citation: LU Wen-Guan, TAO Jia-Xun, LI Xu-Yu, WANG Yu-Zhen. Synthesis, Characterization and Antitumour Activity of Dialkyltin Ferrocenecarboxylates[J]. Chinese Journal of Applied Chemistry, ;2000, 17(2): 126-130. shu

Synthesis, Characterization and Antitumour Activity of Dialkyltin Ferrocenecarboxylates

1.
a Department of Chemistry, Tsinghua University, Beijing 100084;
2.
b Institute of Chemistry, Chinese Academy of Sciences, Beijing

Received Date: 19 July 1999
Available Online: 14 January 2000

Ten dialkyltin complexes (RCO₂)₂SnR'₂[R=Fc,FcCO(CH₂)₂, 4-Fc-C₆H₄, 2-Fc-C₆H₄, FcCH=CH (Fc=ferrocenyl); R'=n-Bu, n-Oct] have been synthesized and characterized by elemental analysis, IR and NMR (¹H, ¹³C) spectroscopy. The results indicated that the Sn atom in these complexes is in a six-coordinated distorted octahedron. The antitumour activity assay results showed that (n-Bu)₂Sn(O₂CR)₂ exhibited a good antitumour activity in vitro against HL-60、HCT-8、BGC-823 and KB tumour cells.
- dialkyltin complex,
- ferrocenecarboxylate,
- synthesis,
- characterization,
- antitumour activity
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