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Citation: LIU Jie, WANG Li-Jun, MEI Wen-Jie, LIU Jian-Zhong, WANG En-Bo, JI Liang-Nian. Activity of Heteropoly Compounds for Anti-Fox encephalitis Virus[J]. Chinese Journal of Applied Chemistry, ;2000, 17(5): 495-498. shu

Activity of Heteropoly Compounds for Anti-Fox encephalitis Virus

1.
a State Key Laboratory of Ultrafast Laser Spectroscopyl, Department of Chemistry, Zhongshan University, Guangzhou 510275;
2.
b Jilin Medical College, Jilin City;
3.
c Department of Chemistry, Northeast Normal University, Changchun

Received Date: 18 December 1999
Available Online: 6 May 2000
Fund Project: 国家自然科学基金(39870895) (39870895)国家新药基金(96-901-05-158)资助项目 (96-901-05-158)

Ten heteropoly compounds were synthesized. Their toxicity to the cells of dog kidney and activity for anti-fox encephalitis virus at nontoxic concentrations were tested by cell culture method. Some of the compounds had high anti-FEV activity at nontoxic concentration, among them HPC-9 had IC₅₀ of 8 mg/L, TC₅₀ of 530 mg/L and TI of 66. The antivirus mechanism of the compounds has been discussed briefly.
- heteropoly compound,
- antivirus activity,
- fox encephalitis virus
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