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Citation: XU Hui, DING Ping-Tian, ZHAO Hui-Ying, ZHENG Jun-Min. Drug Diffusion Behavior of pH-Sensitive PMAA-co-poloxamer Hydrogels[J]. Chinese Journal of Applied Chemistry, ;2001, 18(4): 305-308. shu

Drug Diffusion Behavior of pH-Sensitive PMAA-co-poloxamer Hydrogels

1.
Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110015

Received Date: 10 July 2000
Available Online: 16 October 2000

The pH-sensitive hydrogel networks comprising of MAA and poloxamer were synthesized by free-radical solution polymerization. The gels exhibit pH-dependant solute diffusivity due to the formation or disruption of hydrogen bondings between MAA and EO unit in poloxamer molecules. The values of diffusion coefficients of dextromethorphan (DMP) and vitamin(Vb₁₂) were found in range from 10^-7 to 10^-6 cm²/s in uncomplexed hydrogels(pH 7.0) and from 10^-11 to 10^-8 cm²/s in complexed hydrogels (pH 4.0),respectively. Solute diffusivity decreased as solute size increased. The mole ratio of EO unit to MAA unit is the main factor that affects equilibrium swelling, solute partition and permeability characteristics of these hydrogels.
- hydrogel,
- pH-sensitive,
- equilibrium swelling ratio,
- drug diffusion
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