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Citation: PI Hong-Qiong, WU Jun-Li, YUAN Zhi, HE Bing-Lin. Preparation of Insulin Encapsulated Biodegradable PLA-PEG Copolymer Nanospheres[J]. Chinese Journal of Applied Chemistry, ;2001, 18(5): 365-369. shu

Preparation of Insulin Encapsulated Biodegradable PLA-PEG Copolymer Nanospheres

1.
State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071

Received Date: 19 December 2000
Available Online: 2 April 2001
Fund Project: 国家教委博士点基金(98005504) (98005504)

Nanospheres with entrapped insulin were prepared by a solvent extraction method with a series of copolymers of DL-lactide(PLA) and polyethylene glycol (PEG)(INS/PELA) where the PEG is in different molecular weight and content. The nanospheres as TEM shows have a smooth and spherical surface sized between 100~200 nm. The amount of insulin in nanospheres and the entrapment ratio achieved 17.5% and 87.6%, respectively. In vitro studies indicated that release of insulin from nanospheres could last over 10 days.
- poly (DL-lactide-co-polyethylene glycol),
- biodeg radable,
- nano sphere,
- insulin,
- drug dilivery system
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