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Citation: PAN Fu-You, YANG Jian-Guo, LIANG Hua-Ding, GE Chang-Hua. A Synthetic Route of p-Chlorophenylhydrazine Hydrochloride[J]. Chinese Journal of Applied Chemistry, ;2001, 18(12): 1001-1003. shu

A Synthetic Route of p-Chlorophenylhydrazine Hydrochloride

1.
Department of Chemistry, Taizhou College, Taizhou 317000

Received Date: 8 February 2001
Available Online: 4 September 2001
Fund Project: 浙江省自然科学基金资助课题(293061) (293061)

p-Chlorophenylhydrazine hydrochloride was synthesized from p-chloroaniline through diazotization followed by Na₂SO₃ reduction. The p-chloroaniline is at first diazotized in dilute hydrochloride acid and PEG-600, and then the solution of diazonium hydrochloride was reduced by droping into Na₂SO₃ solution at 70℃, and acided in 20%~25% of hydrochloride acid. The yield was above 84.5%(with purity≥99.5% by HPLC). The following reagent ratios were used in synthesis: n(p-chlorlaniline):n(sodium nitrite):n(hydrochloride acid):n(sodium sulfite)=1.0: 1.02: 3.0: 2.5.
- p-chlorophenylhydrazine hydrochloride,
- diazotization,
- sodium sulfite,
- reduction
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