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Citation: YANG Yun-Song, PENG Hong-Yun, ZHANG Guo-Lin, QI Guo-Rong, YANG Shi-Lin. Transdermal Therapeutic Study of Niclosamide Derivatives[J]. Chinese Journal of Applied Chemistry, ;2001, 18(12): 944-947. shu

Transdermal Therapeutic Study of Niclosamide Derivatives

1.
a Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027;
2.
b Department of Natural Resources Science, Zhejiang University, Hangzhou 310027;
3.
c Department of Pharmacy, Zhejiang University, Hangzhou 310027

Received Date: 28 December 2000
Available Online: 15 May 2001
Fund Project: 国家自然科学基金资助项目(59673017) (59673017)

The low melting point derivatives and the hydrophilic derivatives of niclosamide were designed and prepared to enhance the transdemal rate of niclosamide. Lowering the melting point of niclosamide by esterification with fatty acid did not have much effect on increasing the transdermal flux of niclosamide. However, the trend was evident that the lower the melting point, the greater the transdermal flux. Drugs with suitable octanol/water partition coefficient had great transdermal rate. The transdermal therapeutic system of complexing niclosamide with ethanolamine showed a more promising future than that of niclosamide for schistosomiasis control.
- niclosamide,
- transdermal therapeutic system,
- controlled release
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