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Citation: LAN Zhi-Li, LÜ Yan, XIE Yong-Yao, LIU Zhun, XIE Qing-Lan. Catalytic Synthesis of 4-(4-Chlorophenoxy)-2-chloroacetophenone and Microwave Promotion in the Reaction[J]. Chinese Journal of Applied Chemistry, ;2002, 19(4): 346-350. shu

Catalytic Synthesis of 4-(4-Chlorophenoxy)-2-chloroacetophenone and Microwave Promotion in the Reaction

1.
Key Laboratory of Elemento Organic Chemistry, Nankai University, Tianjin 300071

Corresponding author: XIE Qing-Lan,
Received Date: 30 August 2001
Available Online: 18 December 2001
Fund Project: 加拿大国际开发署资助项目("Microwave Processingin China:Toward Cleaner Industry and Environment".Project No.:282/19736) ("Microwave Processingin China:Toward Cleaner Industry and Environment".Project No.:282/19736)

Ullmann reaction of p-chlorophenol(X) with 2,4-dichloroacetophenone(Ⅺ) was studied as functions of catalysts, solvent, reactants ratio and microwave irradiation. The reaction products were characterized by GC-MS, ¹H NMR and IR techniques. It is found that some catalysts have good regio selectivity for Ullmann reaction. With Cu₂Cl₂ as catalyst, AcNMe ²/Xylene as mixed solvent high yield of target compound was obtained. Microwave irradiation was found to accelerate the reaction.
- diaryl ether,
- microwave irradiation,
- regio selectivity,
- catalysis
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