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Citation: YANG Feng-Ling, WANG Hong-Qing, CAO Hong, LIU Zhao-Jie. Synthesis and Biological Activity of O-Substituted aryl-O-methyl-O-propargyl Thiophosphates[J]. Chinese Journal of Applied Chemistry, ;2002, 19(9): 870-873. shu

Synthesis and Biological Activity of O-Substituted aryl-O-methyl-O-propargyl Thiophosphates

1.
Institute of Organic Synthesis, Central China Normal University, Wuhan 430079

Corresponding author: LIU Zhao-Jie,
Received Date: 8 January 2002
Available Online: 22 April 2002
Fund Project: 国家计划委员会攻关项目(97-563-02-05)资助课题 (97-563-02-05)

Sixteen O-substituted aryl-O-methyl-O-propargyl thiophosphates were synthesized via tandem reaction in dichloromethane by PTC in the presence of triethyl ammonium chloride (TEBAC) and/or tetrabutyl ammonium bromide(TBAB) and triethylene diamine. At condition of m(TEBAC):m(TBAB)=1:1, pH=9~10, 25~35℃, 2.5~3 h thiophosphates were obtained in yields of 60%~97%. The structures of the compounds were characterized by elemental analysis, IR and ¹H NMR spectroscopy. The compound Ⅲ₅(O-4 nitrophenyl-O-methyl-O-propargyl thiophosphate) showed an excellent insecticidal activity against aphid nearly 100% in dosage of 0.025%.
- thiophosphate,
- propargyl,
- synthesis,
- biological activity
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