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Citation: ZHOU Yong-Guo, YANG Yue-Dong, GUO Xue-Min, QI Yin-Ge, BAI Ji-Hai. Preparation and Evaluation of Magnetic Targeting Drug Release Chitosan Microspheres Containing Aspirin[J]. Chinese Journal of Applied Chemistry, ;2002, 19(12): 1178-1182. shu

Preparation and Evaluation of Magnetic Targeting Drug Release Chitosan Microspheres Containing Aspirin

1.
Department of Chemistry, Hebei Vocation-Technical Teachers College, Changli 066600

Corresponding author: YANG Yue-Dong,
Received Date: 16 May 2002
Available Online: 5 August 2002
Fund Project: 河北省教育厅科学基金资助课题(2002223) (2002223)

Chitosan microspheres(CM) were prepared by cross-linking of glutaraldehyde with chitosan solution(mass fraction 10%), and coated with Fe₃O₄ to give magnetic chitosan microspheres(MCM). SEM, IR, atomic absorption spectrometry and UV results indicated that the size of the polymer particles became smaller (<1μm) and more uniformly distributed with decrease of the chitosan molecular weight. In vitro measurement showed the CM entrapped with Aspirin(CM-AS) released about 40% drug, while MCM-AS released 15% in period within one hour. The releasing times for 50% drug were 1.5 h and 5 h, respectively, for CM-AS and MCM-AS. Both MCM and MCM-AS showed strongly magnetic response and promizing applications as targeting drug releasing agent.
- chitosan,
- magnetic chitosan microsphere,
- targeting drug release,
- aspirin
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