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Citation: HUANG Yi, FAN Xiao-Dong. Inclusion Mechanism of β-Cyclodextrin with Chlorambucil[J]. Chinese Journal of Applied Chemistry, ;2003, 20(1): 38-41. shu

Inclusion Mechanism of β-Cyclodextrin with Chlorambucil

HUANG Yi ,
FAN Xiao-Dong ^,

1.
Department of Chemical Engineering, Northwest Polytechnic University, Xi'an 710072

Corresponding author: FAN Xiao-Dong,
Received Date: 29 May 2002
Available Online: 3 September 2002
Fund Project: 陕西省自然科学基金(2000H11)资助项目 (2000H11)

UV-vis spectrophotometric titration was used to calculate the stability constants of an inclusion complex of β-cyclodextrins(β-CD) with chlorambucil(CHL) in different pH buffer solutions at 10℃. The stoichiometry of the inclusion complexes appeared to be 1:1. It was found that there is a stronger inclusion effection in pH=4 buffer solution. Two solid inclusion complexes were obtained with different preparation conditions. The results of DSC and powder X-ray diffraction measurements indicated that novel crystalline structures of inclusion complex were formed under two different conditions. TLC was used to analyze the components of the solid complexes. The results indicated that the hydrolysis of CHL can be efficiently avoided under the low temperature using mixture solvent of alcoholate and water.
- β-cyclodextrin,
- chlorambucil,
- inclusion,
- inclusion stability constants
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