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Citation: YIN Han-Dong, WANG Chuan-Hua, MA Chun-Lin, FANG Hai-Xia, LIU Guo-Fu. Synthesis, Bioactivity and Crystal Structure of Ph₃SnS₂CN(C₄H₈O)[J]. Chinese Journal of Applied Chemistry, ;2003, 20(9): 841-844. shu

Synthesis, Bioactivity and Crystal Structure of Ph₃SnS₂CN(C₄H₈O)

1.
a Department of Chemistry, Liaocheng University, Liaocheng 252059;
2.
b Department of Biology, Liaocheng University, Liaocheng 252059

Corresponding author: YIN Han-Dong,
Received Date: 19 December 2002
Available Online: 9 April 2003
Fund Project: 山东省自然科学基金(Z2001B02)资助项目 (Z2001B02)

Triphenyltin(Ⅳ) dithiomorpholinocarbamate Ph₃SnS₂CN(C₄H₈O) has been synthesized by reacting triphenyltin chloride with sodium dithiomorpholinocarbamate and characterized by elemental analysis, UV, IR and ¹H NMR. The crystal of the compound is monoclinic with space group P2(1)/c, a=1.223 6(5) nm, b=1.167 0(5) nm, c=1.579 1(6) nm, β=99.061(5)°, Z=4, V=2.226 9(15) nm³, D_c=1.528 g/cm³, μ=1.348 mm^-1, R=0.026 2, wR=0.061 5. The structure shows a distorted trigonal bidendate and five-coordinated configuration to the central tin atom. The in vitro antitumor activity of the complex against the human tumor cell lines, MCF-7, a mammary tumor, is examined. The ID 50(μg/L) value is 850.
- triphenyltin(Ⅳ) dithiomorpholinocarbamate,
- synthesis,
- bioactivity,
- crystal structure
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Synthesis, Bioactivity and Crystal Structure of Ph₃SnS₂CN(C₄H₈O)