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Citation: SHEN Run-Pu, PI Shi-Qing, XIE Bin, HUANG Hong-Jun, CHEN Xin-Zhi. An Improved Method for Synthesis of Vitamin A Derivatives via Wittig-Horner Reaction[J]. Chinese Journal of Applied Chemistry, ;2003, 20(12): 1211-1213. shu

An Improved Method for Synthesis of Vitamin A Derivatives via Wittig-Horner Reaction

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College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027
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Corresponding author: CHEN Xin-Zhi,
Received Date: 22 February 2003
Available Online: 10 September 2003
Fund Project: 绍兴市重大科技攻关项目(2003109) (2003109)

Wittig-Horner method for the synthesis of Vitamin A derivatives is improved:3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1,3(or 1,4)-pentadienyl phosphonate is reacted directly with C₅-aldehyde in synthesis and a double bond rearrangment step catalysted by base is curtailed.
- Vitamin A derivative,
- multidoublebound alkylphosphonate ester,
- Wittig-Horner reaction
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