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Citation: LI Ai-Xiu, ZHANG Shu-Ming, DING Feng, YANG Jing-Wu, WANG Jin-Ling. Synthesis and Antibacterial Activity of Phthaloyl and Sebacoyl Hydroxamic Acids[J]. Chinese Journal of Applied Chemistry, ;2004, 21(1): 87-89. shu

Synthesis and Antibacterial Activity of Phthaloyl and Sebacoyl Hydroxamic Acids

1.
a Medical College of Chinese People's Armed Police Forces, Tianjin 300162;
2.
b College of Chemistry and Life, Tianjin Normal University, Tianjin;
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c Nankai High School of Tianjin, Tianjin

Corresponding author: LI Ai-Xiu,
Received Date: 4 April 2003
Available Online: 9 June 2003
Fund Project: 天津市21世纪青年基金(003700711) (003700711)天津市自然科学基金(003601711)资助项目 (003601711)

Four hydroxamic acid derivaties were prepared by reaction of hydroxylamine hydrochloride with dimethylphthalate, dimethylisophthalate, dimethylterephthalate and dimethylsebacate respectively and characterized by IR and elemental analysis. The antibacterial activities to Escherichia coli and Staphylococcus aureus of phthaloyl, isophthaloyl, terephthaloyl and sebacoyl hydroxamic acids have been determined using paper disc method. The result indicates that their antibacterial activities to Escherichia coli are better than that to Staphylococcus aureus and among them the sebacoyl hydroxamic acid is the best one. No linear correlation was observed between the antibacterial activities and the concentration of the compounds, each has its optimum antibacterial concentration.
- phthaloyl hydroxamic acid,
- sebacoyl hydroxamic acid,
- escherichia coli,
- staphylococcus aurous,
- antibacterial activities
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