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Citation: ZHANG Guo-Lin, MA Jian-Biao, WANG Yi-Nong. Synthesis and Characterization of Amphiphilic Diblock Copolymers of Poly (L-Leucine) with Poly (Ethylene Glycol) Monomethyl Ether[J]. Chinese Journal of Applied Chemistry, ;2004, 21(4): 338-342. shu

Synthesis and Characterization of Amphiphilic Diblock Copolymers of Poly (L-Leucine) with Poly (Ethylene Glycol) Monomethyl Ether

1.
State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071

Corresponding author: MA Jian-Biao,
Received Date: 4 June 2003
Available Online: 1 September 2003
Fund Project: 国家自然科学基金(20174018) (20174018)

A series of amphiphilic diblock copolymers poly (L-leucine acid)-b-poly (ethylene glycol) monomethyl ether of lifterent molecular weights were synthesized by the ring-opening polymerization of L-leucine N-carboxy anhydride (NCA) onto amine-terminated poly(ethylene glycol) monomethyl ether (MPEG-NH₂) as a macroinitiator. Their structures and properties were characterized by IR,¹H NMR, DSC, GPC and wateruptake measurements. The results showed that the copolymer samples from the ring opening polymerization of NCA had the expected block structures. The block contents and number-average molecular weights of the copolymers, calculated based on the data of ¹H NMR spectra, could be adjusted by changing the feeding ratio of NCA to the macroinitiator. Owing to incorporation of the hydrophilic MPEG block, the hydrophilicity of these diblock copolymers was much improved than that of the homopolymer poly(L-leucine).
- block copolymer,
- amphiphilic copolymer,
- biodegradable copolymer,
- poly(L-Leucine)-block-poly(ethylene g,
- ycol)monomethyl ether
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