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Citation: PAN Xiang-Bo, LIANG Jing-Juan, LIU Xiong-Min, XIONG De-Yuan, LI Piao-Ying. Lipase Catalyzed Synthesis of Pentadecanolide from 15-Hydroxypentadecanoic Acid[J]. Chinese Journal of Applied Chemistry, ;2004, 21(8): 850-852. shu

Lipase Catalyzed Synthesis of Pentadecanolide from 15-Hydroxypentadecanoic Acid

1.
Industrial Testing & Experiment Center, Guangxi University, Nanning 530004

Corresponding author: LIU Xiong-Min,
Received Date: 29 August 2003
Available Online: 30 December 2003
Fund Project: 教育部科学技术重点项目资助(204110) (204110)广西自然科学基金资助项目(桂科自0135013) (桂科自0135013)

The pentadecanolide was biosynthesized in cyclohexane from 15-hydroxypentadecanoic acid, which as prepared from 15-tetracosenoic acid in Malania Olcifera Chum oil using lipase as catalyst. The effect of lipase activity on the lactonization was investigated. Lipases from fiften strains (13 strains of Candida and 2 strains of Penicillium) showed different catalytic effects to the synthesis reactions. The lipases from strains of Penicillium sp. and 4 strains of Candida sp. have catalytic lactonization activity, and the conversion ratio of substrate reached 88% by using lipase Candida sp.GXU01.
- cyclopentadecanolide,
- lipase,
- hydroxypentadecanoic acid
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