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YANG Yun-Shang, SHI Gao-Feng, LU Run-Hua. Effect of Cyclodextrins on the Solubility of Flavonol Veronicafolin in Water[J]. Chinese Journal of Applied Chemistry,
;2004, 21(11): 1190-1192.
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A high bioactive flavonol veronicafolin was obtained from a Tibetan medicine Chrysosplenium nudicaule Bunge. The supermolecular solubilization of β-cyclodextrin(β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the flavonol has been investigated by a phase solubility method. The results revealed the formation of 1:1 inclusion complex between flavonol and HP-β-CD dramatically increased the solubility of the flavonol, whereas β-CD decreased its solublility. The complex constant Kf for HP-β-CD and flavonol is 4.5×106 L/mol.
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