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Citation: Yubin HUANG, Teruyuki KOMATSU, Eishun TSUCHIDA. Progress on the Totally Synthesized Artificial Red Blood Cell[J]. Chinese Journal of Applied Chemistry, ;2004, 21(11): 1081-1086. shu

Progress on the Totally Synthesized Artificial Red Blood Cell

1.
Advanced Research Institute for Science & Engineering, Waseda University, Tokyo, Japan

Corresponding author: Yubin HUANG,
Received Date: 21 March 2004
Available Online: 2 July 2004

rHSA-heme is the first obtained totally synthesized artificial blood cell substitute. Recombinant albumin associated with synthetic heme has the sufficient capacity to bind and release oxygen molecules under physiological conditions and is practically used in clinical trial with satisfaction. By mixing rHSA-heme with blood in vitro, the concentration of the heme could maintain stable without heme transference. No effect was confirmed on the number of the blood cells, the morphology of the red blood cells and the blood coagulation system. All the rats were survived by injection of rHSA-heme solutions after the hemodilution and hemorrhage, and nearly all the physiological response parameters could be recovered. The safety experiments have also proved that the rHSA-heme solution has no poisonous effect on the function of the rats. rHSA-heme is hope fully to be a new generation of the artificial red blood cell substitute.
- artificial red blood cell,
- rHSA-heme,
- oxygen infusion,
- safety,
- review
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