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Citation: QIU Xiao-Lin, LI Guo-Ming, YE Jun-Sheng. Preparation of Low Molecular Weight Heparin/Chitosan/Alginate Microcapsules and Their Drug-release Performance[J]. Chinese Journal of Applied Chemistry, ;2005, 22(4): 361-366. shu

Preparation of Low Molecular Weight Heparin/Chitosan/Alginate Microcapsules and Their Drug-release Performance

1.
Department of Chemistry, South China Normal University, Guangzhou 510631

Corresponding author: LI Guo-Ming,
Received Date: 28 June 2004
Available Online: 15 October 2004

The microcapsular cores were prepared by dispersing low molecular weight heparin (LMWH) in emulsion,which were encapsulated with chitosan (CS) and then with alginate (ALG) by means of macromolecular self-assembly to form complex microcapsules with a multi-layer structure.The IR results indicated that there were strong electrostatic interactions between LMWH and CS and between CS and ALG.The SEM images showed the LMWH/CS/ALG microcapsules were spherical with an average diameter of (6.9±0.85)μm.The degree of encapsulation of the LMWH was as high as 93.5%.The results of the release kinetics experiments of the microcapsules show that the half-life of LMWH in the microcapsules reached 72 h.With the increase of the concentration of CS or ALG,the LMWH-releasing rate decreases;the higher the mass ratio of LMWH to CS,the faster the drug-release rate of the microcapsules;higher cross-linking degree results in a better drug-release performance;and the drug releases slightly faster in acid media than in alkali ones.
- chitosan,
- alginate,
- low molecular weight heparin,
- microcapsule,
- drug-release performance
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