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Citation: JIAO Fei-Peng, HUANG Ke-Long, PENG Xia-Hui, YU Jin-Gang, ZHAO Xue-Hui, LI Xiao-Gang. Extraction and Separation of Terbutaline Enantiomorph with a Chiral Selector[J]. Chinese Journal of Applied Chemistry, ;2005, 22(8): 818-822. shu

Extraction and Separation of Terbutaline Enantiomorph with a Chiral Selector

1.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083

Corresponding author: HUANG Ke-Long,
Received Date: 10 October 2004
Available Online: 17 March 2005
Fund Project: 国家自然科学基金(20376085) (20376085)湖南省自然科学基金(03JJY3020)资助项目 (03JJY3020)

Distribution behavior of terbutaline enantiomorph was investigated in a aqueous/organic two-phase system containing a chiral selector (L-dihexyltartrate).The influences of organic solvents,lipophilic anions and pH value on the distribution coefficient (k) and the separation factor (α) were investigated.The results show that tetraphenylborate lipophilic anion and terbutaline enantiomorph form two lipophilic salt complexes,which facilitates the solubilization of the enantiomorph in the organic phase.The extraction performance of the two kinds of organic solvent is different,and n-heptane is a better organic solvent.However,pH value of the aqueous phase also influences the extraction performance obviously.Under the determined extraction conditions,a new process of countercurrent liquid membrane extraction technology was adopted to separate terbutaline enantiomorph.To demonstrate the feasibility of the system,mass transfer experiments were performed,in which terbutaline enantiomorph of 99% optical purity can be obtained.
- terbutaline enantiomorph,
- chiral-selector extraction,
- hollow fiber,
- membrane separation
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