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Citation: LIU Chen-Jiang, XIE Zheng-Feng, LI Yan-Ping, ZHAO Gang-Gang, LIU Fang-Ming. Synthesis of Some New Monocyclic Trans-β-Lactams Through Staudinger Cycloaddition[J]. Chinese Journal of Applied Chemistry, ;2005, 22(9): 1042-1044. shu

Synthesis of Some New Monocyclic Trans-β-Lactams Through Staudinger Cycloaddition

1.
College of Chemistry and Chemical Engineering, Xinjiang University, Urumuchi 830046

Corresponding author: LIU Chen-Jiang,
Received Date: 2 November 2004
Available Online: 25 April 2005

In view of the importance of β-lactams in the pharmaceutic research field, a series of pyrazoloderi-vatives of monocyclic β-lactams 2a~2h was prepared from the schiff base 1a~1h reactions with phthalo-ylglycyl chloride in the presence of triethylamine via [2+2] cycloaddition.The structures and configurations of the prepared new monocyclic β-lactams were confirmed by ¹H NMR, ¹H-¹H COSY,NOESY,HMBC,HMQC methods.At 75~85℃,compounds 2a~2h were obtained in yields of 19%~50% respectively.
- pyrazole,
- schiff base,
- cycloaddition,
- monocyclic β-lactam,
- spectral property
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