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Citation: WU Lin-Bo, ZHANG Jun-Chuan, JING Dian-Ying, DING Jian-Dong. A “Room-Temperature” Compression Molding Method for Fabrication of Poly (ε-caprolactone) Porous Scaffolds[J]. Chinese Journal of Applied Chemistry, ;2005, 22(9): 1024-1026. shu

A “Room-Temperature” Compression Molding Method for Fabrication of Poly (ε-caprolactone) Porous Scaffolds

1.
Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Ministry of Education, Fudan University, Shanghai 200433

Corresponding author: DING Jian-Dong,
Received Date: 19 November 2004
Available Online: 19 March 2005
Fund Project: 国家自然科学基金资助项目(20221402,20374015) (20221402,20374015)教育部科学技术研究重大项目(305004) (305004)"九七三"项目、"八六三"项目(2004AA215170) (2004AA215170)上海市科技发展基金(04JC14019)资助 (04JC14019)

A novel room-temperature compression molding method combined with particulate leaching was developed to fabricate porous polyester scaffolds with the anatomical shape of the tissue or organ potentially applied in tissue engineering.Complicated-shaped scaffolds,such as auricle-like ones,were successfully fabricated from compression-molding putty-like mixture of concentrated poly(ε-caprolactone) solution and salt particulate in a mould with a complicated-shaped cavity at room temperature.The resultant porosity can reach over 90%.This room-temperature compression molding method is proven to be very convenient to fabricate three-dimensional porous scaffolds composed of biodegradable polymers.
- tissue engineering,
- porous scaffold,
- biodegradable polymer,
- poly(ε-caprolactone),
- polymer processing
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