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Citation: SHEN Dong-Sheng, LIU Xiao-Fan, YANG Guang-Zhaob. Synthesis of Coumarin Anticoagulant and Its Analogues[J]. Chinese Journal of Applied Chemistry, ;2005, 22(10): 1158-1160. shu

Synthesis of Coumarin Anticoagulant and Its Analogues

1.
a Department of Pharmacy, Guangdong Pharmaceutical University. Guangzhou 510006;
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b Department of Chemistry, Xiangtan University, Xiangtan 411105

Corresponding author: SHEN Dong-Sheng,
Received Date: 9 October 2004
Available Online: 12 February 2005

The condensation reaction of 4-hydroxycoumarin with each of a~h substituted benzalacetones in absolute ethanol gave coumarin analogues which were subsequently converted to their ethyl ethers(cyclocou-marin).The ethers can be quantitatively converted back to the coumarin analogues by acid hydrolysis.Four of them are new substances.The reaction mechanism is discussed in detail.All the products were characterized by HPLC,IR and ¹H NMR.Compared with the present process in the literature,the process for the synthesis of the coumarin analogues is obviously improved on the reaction time,temperature,solvent,catalyst,and post-treatment.
- hydroxycoumarin,
- substituted benzalacetone,
- condensation,
- coumarin analogue
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