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Citation: SUO Zhi-Rong, ZHANG Zun-Ting, ZHENG Jian-Bin. Preparation of Natrium Sulfogenisteinates and Their Anti Peroxidation Activity for Lipids[J]. Chinese Journal of Applied Chemistry, ;2005, 22(10): 1083-1086. shu

Preparation of Natrium Sulfogenisteinates and Their Anti Peroxidation Activity for Lipids

1.
a Institute of Analytical Science/Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an 710069;
2.
b College of Chemistry and Material Science, Shaanxi Normal University, Xi'an

Corresponding author: ZHENG Jian-Bin,
Received Date: 20 December 2004
Available Online: 10 February 2005
Fund Project: 国家自然科学基金(20275030) (20275030)陕西省自然科学基金(2004B20) (2004B20)西北大学中青年基金(03NW29)资助项目 (03NW29)

Genistein(G) has the effects of anti-tumour and anti-arteriosclerosis.It can also reduce plasma lipid and kill various cancer cells without damaging the normal cells.Nevertheless,its medical application is much restricted because of its poor solubility in water and fat.In this study,its two new water-soluble derivatives,genistein-3'-sodium sulfonate(G₁) and genistein-3',6-disodium sulfonate(G₂),were prepared via sulfation and column chromatography separation.The structures of the two compounds were identified by means of IR and ¹H NMR.At the same time,the inhibitory ratios of G,G₁ and G₂ against lipid peroxidation were determined.The results show that G₁ and G₂ not only have stronger anti-peroxidation activity for lipids than G,but also have good water solubilities.
- genistein,
- natrium sulfogenisteinate,
- water-soluble,
- anti-peroxidation
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