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Citation: ZHOU Jin-Lan, YU Kai-Chao. Purification and Antitumor Activity of Major Glucosinolates Separated from Brassica Oleracea Rapeseed[J]. Chinese Journal of Applied Chemistry, ;2005, 22(10): 1075-1078. shu

Purification and Antitumor Activity of Major Glucosinolates Separated from Brassica Oleracea Rapeseed

ZHOU Jin-Lan ,
YU Kai-Chao ^,

1.
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074

Corresponding author: YU Kai-Chao,
Received Date: 25 December 2004
Available Online: 12 April 2005
Fund Project: 国家自然科学基金(No.20275011) (No.20275011)湖北省自然科学基金(2002AB051)资助项目 (2002AB051)

A procedure for the preparative isolation of 1-S-[(1Z)-3-hydroxy-1-[(sulfooxy) imino]-4-(pentenyl)]-1-thio-β-D-glucopyanose,potassium salt(progoitrin) from Brassica oleracea rapeseed is reported.The glucosinolates were extracted from Brassica oleracea rapeseed with a 70% methanol solution;then,the extractives were separated and purified to get the glucosinolates on chromatographic column with alumina support;and finally,the glucosinolates were purified by reverse-phase octadecyl(C₁₈) silica support,and progoitrin was obtained as the major content of glucosinolate.The structure of progoitrin was identified on the basis of its physicochemical properties,UV,IR,¹H NMR and elemental analysis.Its purity was determined by high performance liquid chromatographic(HPLC) method.The anticarcinogenic effects of mixed glucosinolate and pure progoitrin were measured.The experimental results show that when a dose of 60 mg/kg was administrated,the ratio of inhibitory to S₁₈₀ sarcoma was 67.3% and 59.5% for mixed glucosinolates and pure progoitrin,respectively.This study suggests that both the mixture of glucosinolates and pure progoitrin in Brassica oleracea rapeseed have potential anticarcinogenic effect as chempreventive agents.
- glucosinolate,
- separation and purification,
- S₁₈₀,
- anticarcinogenic effects
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