Citation:
YE Yan, LI Xiu-Juan, ZENG Zheng-Zhi. Synthesis, Anti-diabete and Antioxidative Action of Dimethylbiguamide Rare Earth Complexes[J]. Chinese Journal of Applied Chemistry,
;2005, 22(10): 1060-1064.
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Four new complexes were synthesized via reaction of dimethylbiguamide(DMBG) with anhydrous Rare Earth chloride in anhydrous ethanol or Rare Earth acetate in ethanol,and characterized by elemental analysis,ICP,UV,IR,and fluorescence spectroscopy.The formulae of the complexes were established as Nd(DMBG)2(EtO)Cl2(EtO=ethoxy) and Re(DMBG)2(CH3COO)3(Re=Nd(Ⅲ),Sm(Ⅲ)).Their anti-diabetes action on the diabetes mice was observed,and the elimination rates of supraoxide anion free radical on lipid were determinated by ESR.The result shows that Nd(DMBG)2(CH3COO)3 complex exhibits a strong effect in both cases,which implies that its anti-diabetes action may be related to anti-oxidation action or protection effect to membrane damnication.
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