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Citation: YIN Zhi-Gang, XIAO Jin-Qiu, QIAN Heng-Yu, ZHAO De-Feng, H. S. Freeman. Syntheses,Mutagenicity and Application of 2-Amino-10 Hydroxy-5,10-Dihydrophenophosphazine 10-Oxide[J]. Chinese Journal of Applied Chemistry, ;2005, 22(11): 1208-1213. shu

Syntheses,Mutagenicity and Application of 2-Amino-10 Hydroxy-5,10-Dihydrophenophosphazine 10-Oxide

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a School of Material and Chemical Engineering, Zhengzhou Institute of Light Industry, Zhengzhou 450002;
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b State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian;
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c Department of Textile Engineering, Chemistry and Science, North Carolina State University, Raleigh, NC 27695-8302, USA

Corresponding author: YIN Zhi-Gang,
Received Date: 27 December 2004
Available Online: 27 May 2005
Fund Project: 河南省杰出青年基金(0412001100) (0412001100)河南省自然科学基金(0411020400)资助项目 (0411020400)

10-Hydroxy-5,10-dihydrophenophosphazine 10-oxide reacted with acetyl nitryl, viz.,a mixture of acetic acid and concentrated nitric acid to give 10-hydroxy-2-nitro-5,10-dihydrophenophosphazine 10-oxide(74%) which can be further hydrogenated to 2-amino-10-hydroxy-5,10-dihydrophenophosphazine 10-oxide(70%) at pH=7 over 5%Pd/C.The resulting nonmutagenic amino compound(via Salmonella/mammalian microsome assay) was employed as diazo moiety to couple with 3 intermediates containing pyrazolone nucleus to give three different azo dyes.From the investigations of the visible spectra and colorization performances of these azo dyes,it was found that they had deep coloring effects on dyeing wool or silk.In addition,the structures of two intermediates and three azo dyes prepared in this study were determined with spectroscopic techniques.
- dihydrophenophosphazine,
- synthesis,
- structure identification,
- mutagenicity,
- pyrazolone
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