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Citation: DU Zu-Yin, XIAO Ru-Ting. Preparation of a Bis-Quinine Bonded Chiral Stationary Phase and Its Chiral Resolution Ability[J]. Chinese Journal of Applied Chemistry, ;2005, 22(12): 1372-1374. shu

Preparation of a Bis-Quinine Bonded Chiral Stationary Phase and Its Chiral Resolution Ability

DU Zu-Yin ,
XIAO Ru-Ting ^,

1.
School of Biotechnology and Chemical Engineering, Tianjin University of Technology, Tianjin 300191

Corresponding author: XIAO Ru-Ting,
Received Date: 16 February 2005
Available Online: 30 June 2005
Fund Project: 天津市自然科学基金(023606811,033700411)资助项目 (023606811,033700411)

A novel chiral stationary phase(CSP) was prepared by immobilizing coupled quinine,which was synthesized by the reaction of quinine with 4,4'-diphenyl methane diisocyanate(MDI),onto the surface of 3-mercaptopropyl-silanized silica gel via radical reaction in the presence of 2,2'-azobisisobutyronitrile(AIBN).With the conventional slurry packing method,a column was packed with the newly synthesized CSP material.By means of high performance liquid chromatography,the chromatographic properties of this column were tested with five chiral compounds under different mobile phases.The results obtained indicate that chloropheniramine,1,1'-bi-2-naphthol,promethazine and propranolol were resolved into their enantiomers,and their separation factors were 2.08,1.27,1.43 and 1.16,respectively.Furthermore,a possible chiral resolution mechanism was proposed.
- chiral stationary phase,
- quinine,
- high performance liquid chromatography,
- resolution
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