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Citation: LI Jun, LI Quan-Min, WANG Xin-Ming. The Spectrophotometric Determination of Charge Transfer Complex of Azithromycin with 7,7,8,8-Tetracyanoquinodemethane[J]. Chinese Journal of Applied Chemistry, ;2005, 22(12): 1363-1365. shu

The Spectrophotometric Determination of Charge Transfer Complex of Azithromycin with 7,7,8,8-Tetracyanoquinodemethane

LI Jun ^a,c ,
LI Quan-Min ^b ,
WANG Xin-Ming ^a,,

1.
a Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640;
2.
b College of Chemistry and Environmental Science, Henan Normal University, Xinxiang;
3.
c Jiaozuo Teachers' College, Jiaozuo

Corresponding author: WANG Xin-Ming,
Received Date: 26 February 2005
Available Online: 3 June 2005
Fund Project: 中国科学院方向项目(KJZX3-SW-121) (KJZX3-SW-121)广东省自然科学基金团队项目(20003046)资助 (20003046)

A spectrophotometric method for the determination of azithromycin has been developed based on the charge transfer reaction.The reaction between azithromycin and 7,7,8,8-tetracyanoquinodemethane((TCNQ)) was completed in acetone medium in 30 minutes at 50℃.Beer's law is obeyed in the range of 12.1~867.6 mg/L for the determination of azithromycin.The molar absorptivity of the complex at 745 nm is 1.44×10³ L/(mol·cm).The relative standard deviation is 0.96%(n=10).The composition ratio of the charge transfer complex was found to be 1:1 by means of the slope ratio and Job's methods.This method has been applied to the determination of azithromycin in tablets with satisfactory results compared with the Pharmacopoeia method.Recovery was 100.5%.
- charge transfer reaction,
- spectrophtometry,
- azithromycin,
- tetracyanoquinodemethane
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